Journal of South Asian Federation of Obstetrics and Gynaecology

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VOLUME 12 , ISSUE 1 ( January-February, 2020 ) > List of Articles

Original Article

Hyperlipidemia of Pregnancy: Normal or Predictor of Preeclampsia

Suman Chaudhary, Manju Hiranwal, Deepa Chaudhary, Pradeep Dudi

Citation Information : Chaudhary S, Hiranwal M, Chaudhary D, Dudi P. Hyperlipidemia of Pregnancy: Normal or Predictor of Preeclampsia. J South Asian Feder Obs Gynae 2020; 12 (1):31-33.

DOI: 10.5005/jp-journals-10006-1752

License: CC BY-NC 4.0

Published Online: 08-08-2020

Copyright Statement:  Copyright © 2020; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Aim: Pregnant women develop physiological dyslipidemia that can be measured in the laboratory by the lipid indexes. The atherogenic lipid profile of human gestation is further enhanced in preeclampsia. Our study has two purposes. First, the study of the alterations of total cholesterol (TCH), triglycerides (TG), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL), and high-density lipoprotein (HDL) during the pregnancy. The values were compared between early and late pregnancy. Second, the values of women who remained normotensive throughout pregnancy were compared to those who developed hypertension later on. Materials and methods: A total of 500 pregnant women with gestational age of 20 weeks. All of them were followed till delivery and maternal and fetal outcome was noted. Results: Out of 500 pregnant women, 45 were lost to follow-up. The mean age of study population was 23.27 ± 3.54 years. A total of 47 (10.33%) developed preeclampsia–22 had severe and 25 had mild hypertension. All plasma lipid levels increase as gestational age progresses except HDL. This change is statistically significant. It is observed that pregnant women with high TCH and LDL levels at <20 weeks are more likely to develop hypertension later (p value <0.05). Hypertensive pregnant women has very high TCH and LDL levels at >37 weeks (p value <0.05) as compared to normotensive pregnant women. Conclusion: Pregnancy, in general preeclamptic pregnancy, in particular is associated with marked hyperlipidemia. The study suggests that alterations in lipid metabolism observed in preeclampsia are present at early gestational age <20 weeks. Any pregnant women with higher plasma lipid levels may be observed and evaluated for preeclampsia.


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