Journal of South Asian Federation of Obstetrics and Gynaecology

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VOLUME 11 , ISSUE 6 ( November-December, 2019 ) > List of Articles


Frequency of Chromosomal Abnormalities in Products of Conception: A Retrospective, Large-scale, Single-center study

Shailesh Pande, Sunmeet Matkar, Anurita Pais, Gauri Pradhan, Yamini Jadhav, Chaitali Parab, Bharat Kalthe

Keywords : Fluoroscent in situ hybridization, Laboratory research, Products of conception, Recurrent pregnancy losses

Citation Information : Pande S, Matkar S, Pais A, Pradhan G, Jadhav Y, Parab C, Kalthe B. Frequency of Chromosomal Abnormalities in Products of Conception: A Retrospective, Large-scale, Single-center study. J South Asian Feder Obs Gynae 2019; 11 (6):381-384.

DOI: 10.5005/jp-journals-10006-1743

License: CC BY-NC 4.0

Published Online: 25-02-2013

Copyright Statement:  Copyright © 2019; The Author(s).


Background: The cause of miscarriage is successfully elucidated by analyzing the cytogenetic analysis of the retained products of conception (POC). From our understanding, we have not come across any large population-based study in India that analyzed the POC for identifying the cause of miscarriage. Objectives: This laboratory-based research study aimed at finding the incidences of chromosomal defects from large number of POC samples received from tertiary care laboratory. Materials and methods: The current study comprises retrospective analysis involving cytogenetic reports of large number of cases (n = 1,732) undertaken at the Department of Cytogenetics, Metropolis Healthcare Laboratory, Mumbai, India, between January 2014 and December 2016. Results: Karyotypes with no abnormal findings were recorded in 82.97% cases, whereas aneuploidy was detected in 17.03% cases. Among the aneuploidy cases, they were further categorized into monosomy X (38.14%), trisomy (36.02%), double trisomy (0.85%), triploidy (15.25%), tetraploidy (8.90%), and derivatives (0.85%). Among the total study cases, 76.33% and 23.67% showed female pattern and male pattern, respectively. Conclusion: Evaluation of POC is of immense help for the cases with history of recurrent/repeated pregnancy loss (RPL)/losses. Early detection of chromosomal aberrations will support the treating physician toward correct reasons for RPL. Also, it also helps to rule out the possibility of gonadal cell mosaicism in cases with RPL having a normal karyotype. Cases with abnormal findings are highly recommended for genetic counseling.

  1. TMA Teles, Marques de Paula CM, Ramos MG, et al. Frequency of chromosomal abnormalities in products of conception. Rev Bras Ginecol Obstet 2017;39(3):14.
  2. Wan TSK. Cancer cytogenetics: Methodology revisited. Ann Lab Med 2014;34(6):413–425. DOI: 10.3343/alm.2014.34.6.413.
  3. Shah MS, Cinnioglu C, Maisenbacher M, et al. Comparison of cytogenetics and molecular karyotyping for chromosome testing of miscarriage specimens. Fertil Steril 2017;107(4):1028–1033. DOI: 10.1016/j.fertnstert.2017.01.022.
  4. Moraes AC, Moron AF, Hashimoto EM, et al. Cytogenetic and molecular evaluation of spontaneous abortion samples. Rev Bras Ginecol Obstet 2005;27(9):554–560. DOI: 10.1590/S0100-72032005000900009.
  5. López AGA, Huerta SB, Galván RH, et al. Diagnóstico citogenético en aborto espontáneo del primer trimestre. Ginecol Obstet Méx 2003;79(12):779–784.
  6. Liu S, Song L, Cram DS, Xiong L, et al. Traditional karyotyping vs copy number variation sequencing for detection of chromosomal abnormalities associated with spontaneous miscarriage. Ultrasound Obstet Gynecol 2015;46(4):472–477. DOI: 10.1002/uog.14849.
  7. Lathi G, Gray Hazard RB, Heerema-McKenney FK, et al. First trimester miscarriage evaluation. Semin Reprod Med 2011;29(6):463–469. DOI: 10.1055/s-0031-1293200.
  8. Wan TS, Ma ES. Molecular cytogenetics: an indispensable tool for cancer diagnosis. Chang Gung Med J 2012;35(2):96–110. DOI: 10.4103/2319-4170.106161.
  9. Wan TS, Ma ES. The role of FISH in hematologic cancer. Int J Hematol Oncol 2012;1(1):71–86. DOI: 10.2217/ijh.12.9.
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