Background: The cause of miscarriage is successfully elucidated by analyzing the cytogenetic analysis of the retained products of conception (POC). From our understanding, we have not come across any large population-based study in India that analyzed the POC for identifying the cause of miscarriage. Objectives: This laboratory-based research study aimed at finding the incidences of chromosomal defects from large number of POC samples received from tertiary care laboratory. Materials and methods: The current study comprises retrospective analysis involving cytogenetic reports of large number of cases (n = 1,732) undertaken at the Department of Cytogenetics, Metropolis Healthcare Laboratory, Mumbai, India, between January 2014 and December 2016. Results: Karyotypes with no abnormal findings were recorded in 82.97% cases, whereas aneuploidy was detected in 17.03% cases. Among the aneuploidy cases, they were further categorized into monosomy X (38.14%), trisomy (36.02%), double trisomy (0.85%), triploidy (15.25%), tetraploidy (8.90%), and derivatives (0.85%). Among the total study cases, 76.33% and 23.67% showed female pattern and male pattern, respectively. Conclusion: Evaluation of POC is of immense help for the cases with history of recurrent/repeated pregnancy loss (RPL)/losses. Early detection of chromosomal aberrations will support the treating physician toward correct reasons for RPL. Also, it also helps to rule out the possibility of gonadal cell mosaicism in cases with RPL having a normal karyotype. Cases with abnormal findings are highly recommended for genetic counseling.