Journal of South Asian Federation of Obstetrics and Gynaecology

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VOLUME 11 , ISSUE 6 ( November-December, 2019 ) > List of Articles

Original Article

A Prospective Study to Compare the Maternal and Fetal Outcomes among Sickle Cell Disease and Trait Women

Santosh Kumar Dora, Atal B Dandapat, Benudhar Pande, Ganeshram Bhoi, Bhawana Tiwari

Keywords : Sickle cell anemia, Sickle cell crisis, Sickle cell disease, Sickle cell trait

Citation Information : Dora SK, Dandapat AB, Pande B, Bhoi G, Tiwari B. A Prospective Study to Compare the Maternal and Fetal Outcomes among Sickle Cell Disease and Trait Women. J South Asian Feder Obs Gynae 2019; 11 (6):340-344.

DOI: 10.5005/jp-journals-10006-1724

License: CC BY-NC 4.0

Published Online: 25-12-2012

Copyright Statement:  Copyright © 2019; The Author(s).


Introduction: We conducted a prospective trial to compare the maternal and fetal outcomes between the sickle cell disease (SCD) and sickle cell trait (SCT) pregnant patients. Materials and methods: From December 2015 to December 2016, a total of 59 patients were diagnosed with SCD and 119 patients with SCT. All the fetal and maternal parameters were compared between them. Results: A total of 17 (28.8%) SCD and 5 (4.2%) SCT patients presented with painful crisis. Acute chest syndrome developed in 9 (15.3%) of SCD and 1 (0.8%) of SCT cases. Hemolytic crisis was seen in 4 (6.8%) of SCD patients. The incidence of hypertension, preeclampsia, jaundice, blood transfusion during pregnancy, and IUGR among the SCD and SCT patients were 11 (18.6%) vs 5 (4.2%) (p = 0.000), 19 (32.2%) vs 7 (5.9%) (p = 0.000), 15 (25.4%) vs 0 (0%) (p = 0.000), 36 (61%) vs 8 (6.7%) (p = 0.000), and 33 (55.9%) vs 21 (17.6%) (p = 0.000), respectively. The mean periods of gestation of delivery were significantly lower, i.e., 36.5 ± 2.76 weeks for SCD patients compared to 38.2 ± 2.1 weeks for SCT patients (p = 0.000). Ten (16.9%) of SCD and one (0.8%) of SCT patients had intrauterine death. Average birth weights of babies delivered were 2142 ± 557.45 g and 2684 ± 551.23 g for SCD and SCT patients, respectively. Conclusion: Sickle cell anemia causes an increased risk to both mother and fetus. Sickle cell disease women are more prone to develop sickle cell crisis as well as increased obstetrical complication. A preconceptional counseling of all sickling women with a multidisciplinary approach can prevent many of the maternal and fetal complications during pregnancy.

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