Journal of South Asian Federation of Obstetrics and Gynaecology

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VOLUME 11 , ISSUE 2 ( March-April, 2019 ) > List of Articles

RESEARCH ARTICLE

Hemodynamic Profile and Cardiac Morphometry in Normotensive and Severe Preeclamptic Pregnant Women

Peby Lestari, Edo Alexander

Keywords : Cardiac morphometry, Early onset PE, Hemodynamic profile, Late-onset PE, Normotensive

Citation Information : Lestari P, Alexander E. Hemodynamic Profile and Cardiac Morphometry in Normotensive and Severe Preeclamptic Pregnant Women. J South Asian Feder Obs Gynae 2019; 11 (2):113-119.

DOI: 10.5005/jp-journals-10006-1677

License: CC BY-NC 4.0

Published Online: 01-06-2019

Copyright Statement:  Copyright © 2019; The Author(s).


Abstract

Objective: To identify the differences in hemodynamic profile and morphometric changes of maternal heart in normotensive pregnant women and severe preeclampsia. Materials and methods: Cross-sectional study was conducted on 34 pregnant women divided into three groups: normotensive (n = 12), early-onset (n = 11), and the late-onset (n = 11). Subjects were patient from ER and inpatient unit of the Department of Obstetrics and Gynecology, Faculty of Medicine, Sriwijaya University/Dr Mohammad Hoesin Hospital, Palembang, during April–June 2015. Results: CO values of the early onset group was lower (3.4 + 0.27, p < 0.001) with higher SVR (3100.2 + 261.3, p < 0.001) than the other two groups. SVR in preeclamptic group was higher compared to the control, the early onset presenting higher SVR than the late-onset group (3100.2 + 261.3 vs 2217.1 + 407.8, p < 0.001). Cardiac index variables between groups were also different, except in the early onset group and controls (p = 0.045). In blood pressure and MAP variable, we only noticed difference between the early onset group and control (p < 0.001) as well as late-onset group and controls (p < 0.001). LVMi, LVID and LVPWT in control group was lower than the others (p < 0.001; p = 0.049; p = 0.009), but were similar for the early onset and late-onset groups [98.7 (86.5–203) vs 132 (77.7–17.6); 4.7 (0.4) vs 4.8 (0.5); 1.1 (0.7–1.3) vs 1.1 (0.8–1.6)]. RWT was relatively similar across the three arms of the study (p = 0.264). Conclusion: In severe preeclampsia, there are changes in hemodynamic, ventricular morphometry, and left ventricular function, which is more evident in the group of early-onset preeclampsia than late-onset preeclampsia.


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