Journal of South Asian Federation of Obstetrics and Gynaecology

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VOLUME 11 , ISSUE 2 ( March-April, 2019 ) > List of Articles

Original Article

Effectiveness of Isosorbide Mononitrate in Cervical Ripening before Induction of Labor in Full-term Antenatal Patients

Mohit Agrawal, Neema Acharya, Ketav Joshi, Deepti Shrivastava

Keywords : Bishop score, IMN, Induction of Labor

Citation Information : Agrawal M, Acharya N, Joshi K, Shrivastava D. Effectiveness of Isosorbide Mononitrate in Cervical Ripening before Induction of Labor in Full-term Antenatal Patients. J South Asian Feder Obs Gynae 2019; 11 (2):96-99.

DOI: 10.5005/jp-journals-10006-1668

License: CC BY-NC 4.0

Published Online: 01-06-2019

Copyright Statement:  Copyright © 2019; The Author(s).


Abstract

Aim: The aim of the present study is to prove the efficacy of isosorbide mononitrate (IMN) as a cervical ripening agent before induction of labor in term pregnancies. Materials and methods: The present study was prospective and comparative, experimental randomized placebo-controlled, double-blind study conducted in the Department of Obstetrics and Gynaecology at Acharya Vinoba Bhave Rural Hospital, Sawangi (Meghe), Wardha, over a period of two years extending from September 2014 to August 2016. Results: There was a marked improvement in Bishop's score in study group as compared to control group. The mean baseline Bishop's score in case group was 2.65 + 1.29 and 2.64 + 1.26 in control group. Bishop's score after the 1st dose (i.e., 24 hours after admission) in study group was 5.95 + 1.56 and 3.43 + 1.35 in control group; p value is 0.001 which was statistically significant while Bishop's score after the 2nd dose (i.e., 24 hours after the second dose and 48 hours after admission) in study group was 7.73 + 2.26 and 4.47 + 1.73 in control group. Conclusion: Isosorbide mononitrate is effective and safe when used for cervical ripening before induction of labor at term without causing any side effect on maternal hemodynamic and hyperstimulation of uterus.


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