Citation Information :
Agrawal M, Acharya N, Joshi K, Shrivastava D. Effectiveness of Isosorbide Mononitrate in Cervical Ripening before Induction of Labor in Full-term Antenatal Patients. J South Asian Feder Obs Gynae 2019; 11 (2):96-99.
Aim: The aim of the present study is to prove the efficacy of isosorbide mononitrate (IMN) as a cervical ripening agent before induction of labor in term pregnancies.
Materials and methods: The present study was prospective and comparative, experimental randomized placebo-controlled, double-blind study conducted in the Department of Obstetrics and Gynaecology at Acharya Vinoba Bhave Rural Hospital, Sawangi (Meghe), Wardha, over a period of two years extending from September 2014 to August 2016.
Results: There was a marked improvement in Bishop's score in study group as compared to control group. The mean baseline Bishop's score in case group was 2.65 + 1.29 and 2.64 + 1.26 in control group. Bishop's score after the 1st dose (i.e., 24 hours after admission) in study group was 5.95 + 1.56 and 3.43 + 1.35 in control group; p value is 0.001 which was statistically significant while Bishop's score after the 2nd dose (i.e., 24 hours after the second dose and 48 hours after admission) in study group was 7.73 + 2.26 and 4.47 + 1.73 in control group.
Conclusion: Isosorbide mononitrate is effective and safe when used for cervical ripening before induction of labor at term without causing any side effect on maternal hemodynamic and hyperstimulation of uterus.
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