Citation Information :
Magno A, Alas QM, Sung C. False-positive Positron Emission Tracing/Computed Tomography Secondary to Suture Granuloma Formation in Early-stage Endometrial Cancer. J South Asian Feder Obs Gynae 2019; 11 (1):73-76.
Suture granuloma formation can cause abnormal radiotracer uptake of 2-deoxy-2-[18F] fluoro-D glucose (FDG) in positron emission tracing/computed tomography (PET/CT) scan. It can be formed secondary to usage of silk suture during surgery as part of delayed host inflammatory reaction to a foreign body. Here, we report a case of a 61-year-old woman diagnosed with endometrial cancer who underwent tumor debulking surgery secondary to abnormal radiotracer uptake in PET/CT suspected as tumor recurrence which on histology revealed suture granuloma.
Kitajima K, Suenaga Y, Ueno Y, Maeda T, Ebina Y, Yamda H, et al. Preoperative risk stratification using metabolic parameters of (18)F-FDG PET/CT in patients with endometrial cancer. Eur J Nucl Med Mol Imaging 2015;42(8):1268-1275.
Bollineni VR, Ytre-Hauge S, Bollineni-Balabay O, Salvesen HB, Haldorsen IS. High diagnostic value of 18F-FDG PET/CT in endometrial cancer: systematic review and meta-analysis of the literature. Journal of Nuclear Medicine. 2016 Jun 1;57(6):879-885.
Lee SI, Catalano OA, Dehdashti F. Evaluation of gynecologic cancer with MR imaging, 18F-FDG PET/CT, and PET/MR imaging. J Nucl Med 2015;56(3):436-443.
Tirumani SH, Shanbhogue AK, Prasad SR. Current concepts in the diagnosis and management of endometrial and cervical carcinomas. Radiol Clin North Am 2013;51(6)1087-1110.
Chung HH, Kang KW, Cho JY, Kim JW, Park NH, Song YS, et al. Role of magnetic resonance imaging and positron emission tomography/computed tomography in preoperative lymph node detection of uterine cervical cancer. Am J Obstet Gynecol 2010;203(2):156.e1-e5.
Fennel J, Scholber J, Grodsu AL, Volegova-Neher N, Henne K, Langer M, et al. MRI and FDG-PET/CT imaging in gynecological malignancies: the radiation oncology perspective. Q J Nucl Med Mol Imaging 2016;60(2):117-123.
Signorelli M, Crivellaro C, Buda A, Guerra L, Fruscio R, Elisei F, et al. Staging of high-risk endometrial cancer with PET/ CT and sentinel lymph node mapping. Clin Nucl Med 2015;40(10):780-785.
Nakajo M, Nakajo M, Nakayama H, Jinguji M, Nakabeppu Y, Higashi M, et al. Dexamethasone suppression FDG PET/CT for differentiating between true- and false-positive pulmonary and mediastinal lymph node metastasis in non-small cell lung cancer: a pilot study of FDG PET/CT after oral administration of dexamethasone. Radiology 2016;279(1):246-253.
Rosenbaum SJ, Lind T, Antoch G, Bockisch A. False-positive FDG PET uptake – the role of PET/CT. Eur Radiol 2006;5:1054- 1065.
Kikuchi M, Nakamoto Y, Shinohara S, Fujiwara K, Tona Y, Yamakazi H, et al. Suture granuloma showing false-positive finding on PET/CT after head and neck cancer surgery. Auris Nasus Larynx 2012;39(1):94-97.