Journal of South Asian Federation of Obstetrics and Gynaecology

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VOLUME 11 , ISSUE 1 ( January-February, 2019 ) > List of Articles

RESEARCH ARTICLE

Multidrug Regimen for Prevention of Mother-to-child Transmission in Human Immunodeficiency Virus-positive Mothers in India—From Prevention toward Elimination

Rekha G Daver, Muskaan Chhabra

Keywords : Antenatal, Human immunodeficiency virus, Multidrug regimen, Neonatal outcome, Prevention of mother-to-child transmission

Citation Information : Daver RG, Chhabra M. Multidrug Regimen for Prevention of Mother-to-child Transmission in Human Immunodeficiency Virus-positive Mothers in India—From Prevention toward Elimination. J South Asian Feder Obs Gynae 2019; 11 (1):50-57.

DOI: 10.5005/jp-journals-10006-1649

License: CC BY-NC 4.0

Published Online: 01-12-2017

Copyright Statement:  Copyright © 2019; The Author(s).


Abstract

Objectives: To study the incidence, demographics, and course till delivery of HIV positive women on multidrug regimen for prevention of mother-to-child transmission (PMTCT). To study the efficacy of this regimen, neonatal outcome and human immunodeficiency virus (HIV) status in infants of these women to detect transmission. Design: Prospective observational study. Duration: 20 months (01/03/2014–31/10/2015). Setting: Department of Obstetrics and Gynaecology at a Tertiary Health Care Center in Mumbai, Maharashtra, India. Population or sample: The HIV-positive antenatal women attending outpatient department (OPD) or admitted in wards. Sample size: 93. Materials and methods: All HIV positive pregnant women were, after consent and counseling, started on tenofovirlamivudine- efavirenz (TLE) regimen for HIV prophylaxis. Those women who were already on ART were continued on the same regimen. Post-delivery syrup nevirapine was given to the baby for 6 weeks. Main outcome measures: To study transmission of HIV to the baby by testing at 6 weeks, 6 months, 12 months and 18 months. Results: Of the 93 babies,13 babies were lost to neonatal death and stillbirth. Of the 80 live-born infants, 6 were lost to follow-up. Hence, 74 infants were tested at 6 weeks, 6 months, 12 weeks and 18 months of age. All the 74 tested babies were seronegative. Conclusion: The use of multidrug regimen (as per WHO B+), even in resource-limited settings gives astonishing results with no baby found to be seropositive thus showing us the way forward from prevention to elimination.


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