Cervical Cytology and its Correlation with Cervicovaginal Infection in Antenatal Patients: A Study in a Tertiary Care Hospital
Jai Kishan Goel, Akansha Mani, Rahul Goyal, Milan Jaiswal, Shanti Sah
Cervical intraepithelial neoplasia, Human papillomavirus, Pap smear, Wet mount
Citation Information :
Goel JK, Mani A, Goyal R, Jaiswal M, Sah S. Cervical Cytology and its Correlation with Cervicovaginal Infection in Antenatal Patients: A Study in a Tertiary Care Hospital. J South Asian Feder Obs Gynae 2018; 10 (4S1):293-296.
Aim: To study cervical cytology and cervicovaginal infection in antenatal women.
Objectives: To find out by pap smear for inflammatory, atypical squamous cells of undetermined significance (ASCUS), atypical glandular cells of undetermined significance (AGUS) and premalignant lesions in antenatal women.
• To find out cervicovaginal infection by wet mount among antenatal women.
• Correlation of cervical cytology with cervicovaginal infection.
Materials and methods: Five hundred antenatal women, irres- pective of gestational age, were enrolled as subjects in this prospective clinical study for blood investigations, wet mount examination of cervical discharge and pap smear.
Results: Out of 500 smears, 385 women were having inflammatory smears out of which 301 were having bacterial vaginosis followed by 89 vaginal candidiasis followed by 12 were having trichomoniasis, in which 339 had a preterm delivery.
Conclusion: Antenatal visits are a potential opportunity to perform screening by Pap smear and wet mount study to prevent preterm labor and improve perinatal mortality.
Ferlay J, Autier P, et al. Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol 2007;18(3):581-592.
Bidus MA, Elkas JC, et al. Cervical and vaginal cancer. Bereck and Novac's gynecology. 14th edition. Philadelphia: Wolters Kluwer Publishers; 2009.
Bandyopadhyay S, Chatterjee R. HPV Viral load determination during pregnancy as a possible cervical cancer risk. J Exp Clin Cancer Res 2006;25(1):29-38.
Hildesheim A, Herrero R, et al. HPV co-factors related to the development of cervical cancer: results from a population-based study in Costa Rica. Br J Cancer 2001;84:1219-1226.
International Collaboration of Epidemiological studies of cervical cancer. Cervical carcinoma and reproductive factors: Collaborative reanalysis of individual data on 16,563 womenwith cervical carcinoma and 33,542 women without cervical carcinoma from 25 epidemilogical studies. Int J Cancer 2006;119:1108-1124.
Smith JS, Green J, et al. Cervical cancer and use of hormonal contraceptive; a systematic review. Lancet 2003;361:1159-1167.
Ylitalo N, Sorensen P, et al. smoking and oral contraceptives as risk factors for cervical carcinoma in situ. Int J Cancer 1999;81:357-365.
Dalrymple JL, Gilbert WM, et al. Pregnancy-associated cervical cancer: obstetric outcomes. J Mat Fetal Neonatal Med 2005;17:269-279.
Sweet RL. Gynaecologic conditions and bacterial vaginosis: implications for the non-pregnant patient. Infect Dis Obstet Gynecol 2008,8:184-190.
Khaengkhor P, Mairaing K, et al. Prevalence of abnormal cervical cytology by liquid based cytology in the antenatal care clinic, Thammasat University Hospital. J Med Assoc Thai 2011;94(2):152-158.
Neelima B, Vanamala VG, et al. The incidence of cervical intraepithelial neoplasia in antenatal women by screening: a study in a semi urban area in Telangana, India. Int J Reprod Contracep Obstet Gynecol 2017;6(7):2887-2890.
Ingprasarn A, Onaium N. Prevalence of Abnormal Conventional Pap Smear in Pregnant Women, Chonburi Hospital. Thai J Obstetr Gynaecol 2014 Sep 30:137-142.
Manikkam B. Screening for cervical cancer during pregnancy. Int J Community Medicine and Public Health 2016;3(9):2493-2498.
Himabindu P, Kanwal A, et al. Pap smear in antenatal women-routine screening in low resource settings. IOSR J Dent Med Sci 2015;14(4I):04-05.
Barouti E, Farzaneh F, et al. The pathogenic microorganisms in papnicoloau vaginal smears and correlation with inflammation. J Fam Reprod Health 2013;7(1):23-27.
Govender L, Hoosen AA, et al. Bacterial vaginosis and associated infections in pregnancy. Int J of Gynecol and Obstet 1996;55(1):23-28.
Gupta A, Garg P, et al. Bacterial vaginosis in pregnancy (<28 weeks) and its effect on pregnancy outcome: A study from a western UP city. Indian J Clin Prac 2011;23:740-744.
Baka S, Tsirmpa I, et al. Inflammation on the cervical papanicoloau smear: Evidence for infection in asymptomatic women? Infect Dis Obstetr Gynecol 2013;2013:184302.