Background: The increased level of the placental proinflammatory cytokines, vasoconstrictors and lipid peroxidation products is known to be involved in the pathogenetic scenario of pre-eclampsia. Systemic inflammatory response syndrome captures the severity of pre-eclampsia (PE). The opinion about the possible role of infection in the origin and progression of pre-eclampsia is rather unpopular nowadays. Aim: To elucidate the involvement of the infectious agents in the pathogenesis of multiple organ failure syndrome in preeclampsia. Case report: An unusual case of the prodromal symptoms of eclampsia and systemic inflammatory response syndrome in the postpartum period associated with group B streptococcus infection was reported. But the resistant to the cephalosporins microbial flora was a reason for the progression severity of preeclampsia and puerperal sepsis. Since uterus was the source of sepsis the hysterectomy procedure has given a possibility to avoid general peritonitis and septic shock. Conclusion: The infectious inflammation could be involved in the pathogenesis of PE and contribute to the progressive severity of the disease.