Prediction of Pregnancy-induced Hypertension by Maternal Serum Beta Human Chorionic Gonadotropin Levels in Early Second Trimester of Pregnancy
Anuja V Bhalerao, Sanyukta S Dawle
Beta human chorionic gonadotropin, Preeclampsia, Pregnancy-induced hypertension
Citation Information :
Bhalerao AV, Dawle SS. Prediction of Pregnancy-induced Hypertension by Maternal Serum Beta Human Chorionic Gonadotropin Levels in Early Second Trimester of Pregnancy. J South Asian Feder Obs Gynae 2018; 10 (2):104-109.
Objective: The study aims at testing the hypothesis that women with high serum beta human chorionic gonadotropin (β-hCG) in early second trimester have risk of developing pregnancy-induced hypertension and poor maternal and neonatal outcome. Early identification of at-risk women may help in taking timely preventive and curative management to prevent or delay complications associated with pregnancy-induced hypertension.
Materials and methods: Serum β-hCG was done in 400 antenatal women between 12 and 24 weeks of gestation and they were followed up till delivery and postpartum for 7 days. Assessment of serum β-hCG and its predictability for development of pregnancy-induced hypertension and its effect on maternal and fetal outcome were done.
Results: Women with high serum β-hCG levels at 12 to 24 weeks of gestation have 1.67 times more risk of developing pregnancy-induced hypertension (p = 0.035) and poor maternal and perinatal outcome.
Conclusion: Elevated maternal serum β-hCG at early second trimester is a good noninvasive predictor of pregnancy-induced hypertension. The maternal and perinatal outcome was directly proportional to levels of serum β-hCG.
Duley L. The global impact of preeclampsia and eclampsia.Semin Perinatol 2009 Jun;33(3):130-137.
Sibai BM. Diagnosis and management of gestational hypertension and preeclampsia. Am J Obstet Gynecol 2003 Jul;102(1):181-192.
Brazy JE, Grimm JK, Little VA. Neonatal manifestations of severe maternal hypertension occurring before the thirty-sixth week of pregnancy. J Pediatr 1982 Feb;100(2):265-271.
Gifford RW, August PA, Cunningham G. National High Blood
Am J Obstet Gynecol 2000 Jul;183(1):S1-S22.
Sibai BM. Diagnosis and management of gestational hypertension and preeclampsia. Obstet Gynecol 2005;110-121.
Vidyabati RK, Hijam D, Singh NK, Singh WG. Serum beta human chorionic gonadotropin (â hCG) and lipid profile in early second trimester as predictors of pregnancy induced hypertension. J Obstet Gynecol India 2014;60(1);44-50.
Singh U, Yadav S, Mehrotra S, Natu SM, Kumari K,Yadav YS. Serum lipid profile in early pregnancy as predictor of preeclampsia. International journal of Medical Research and Review 2013 Apr-Jun;1(2):56-62.
Ephraim R, Doe PA, Amoah S, Antoh EO. Lipid profile and high maternal body mass index is associated with preeclampsia:a case-control study of the Cape Coast Metropolis. Ann Med Health Sci Res 2014 Sep;4(5):746-750.
Kiran Y, Aggarwal S, Verma K. Serum beta hCG and lipid profile in early second trimester as predictors of pregnancy induced hypertension. J Obstet Gynaecol India 2014 Jun;64(3):169-174.
Siddiqui IA. Maternal serum lipids in women with pre eclampsia.Ann Med Health Sci Res 2014 Jul-Aug;4(4):638-641.
Remzi G, Erdal A, Nursel B, Ozcan B. Elevated serum beta hCG levels in severe preeclampsia. Turk J Med Sci 2000;30(1):43-45.
Wander G. Can early second trimester serum beta hCG, serum cholesterol markers of subsequent hypertensive disorders of pregnancy. RCOG 2013.
Vrijkotte TG, Krukziener N, Hutten BA, Vollebregt KC,van Eijsden M, Twickler MB. Maternal lipid profile during early pregnancy and pregnancy complications and outcomes:The ABCD study. J Clin Endocrinol Metab 2012 Nov;97(11):3917-3925.