Journal of South Asian Federation of Obstetrics and Gynaecology

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VOLUME 10 , ISSUE 2 ( April-June, 2018 ) > List of Articles

ORIGINAL ARTICLE

Effects of CD4 Level on Abnormal Cervical Cytology in HAART-naïve HIV-seropositive Women

Sujidtra Neamtan, Sitchuphong Noothong, Ascharavadee Pulsawat

Keywords : Abnormal cervical cytology, Cluster of differentiation 4 level, Highly active antiretroviral therapy-naïve human immunodeficiency virus-seropositive women

Citation Information : Neamtan S, Noothong S, Pulsawat A. Effects of CD4 Level on Abnormal Cervical Cytology in HAART-naïve HIV-seropositive Women. J South Asian Feder Obs Gynae 2018; 10 (2):84-87.

DOI: 10.5005/jp-journals-10006-1566

Published Online: 01-06-2018

Copyright Statement:  Copyright © 2018; The Author(s).


Abstract

Aim: To study the effects of cluster of differentiation 4 (CD4) level on abnormal cervical cytology in human immunodeficiency virus (HIV)-infected women who have not received highly active antiretroviral therapy (HAART). Materials and methods: Retrospective cross-sectional study was carried at Hatyai Hospital from October 1, 2010 to June 30, 2016. Medical records of 270 HIV-infected women who have not received HAART and have been screened for cervical cancer with Pap smear were reviewed. The CD4 level has been evaluated in all patients. Participants were divided into two groups: 135 patients with CD4 < 200 cells/ìL (low CD4 group) and 135 patients with CD4 at least 200 cells/ìL (high CD4 group). Statistical analysis was performed. Results: The prevalence of abnormal cervical cytology in HIVinfected women who have not received HAART was 25.9%. There was difference in prevalence of abnormal cervical cytology between low and high CD4 groups (37.8 vs 17.0%) with statistical significance (p = 0.001). Odds ratio was 2.60 (95% confidence interval: 1.47–4.61). Conclusion: The low CD4 level (CD4 < 200 cells/ìL) in HIVinfected women who did not receive HAART increased risk of abnormal cytology of 2.6 folds, compared with high CD4 level (CD4 at least 200 cells/ìL). The prevalence of abnormal cervical cytology in HIV-infected women who have not received HAART was 25.9%. Clinical significance: Human immunodeficiency virus infection is the significant risk factor of cervical cancer. The authors evaluated the effects of CD4 level on abnormal cervical cytology in women who have not received HAART.


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  1. Ferlay, J.; Soerjomataram, I.; Ervik, M.; Dikshit, R.; Eser, S.; Mathers, C.; Rebelo, M.; Parkin, DM.; Forman, D.; Bray, F. GLOBOCAN 2012: estimated cancer incidence, mortality and prevalence worldwide in 2012. France: International Agency for Research on Cancer; 2012. Available from: http://globocan. iarc.fr/Pages/fact_sheets_population.aspx.
  2. National Cancer institute. Department of Medical Services Ministry of Public Health Thailand. Hospital based cancer registry annual report 2013. Bangkok: National Cancer Institute, Department of Medical Services, Ministry of Public Health; 2015.
  3. ICO/IARC HPV Information Centre. Human papillomavirus and related cancers, Thailand. Fact Sheet 2015. Spain: ICO/ IARC; 2015 [cited 2015 Dec 18]. Available from: http://www. hpvcentre.net/statistics/reports/THA_FS.pdf.
  4. Laowahutanont, P.; Chaiweerawattana, A.; Sukyothin, S.; Im-samran, W.; Kuhapremma, T. Guidelines for screening, diagnosis and treatment of cervical cancer. Bangkok: National Cancer Institute, Department of Medical Services Ministry of Public Health Thailand; 2013.
  5. Bureau of AIDS, TB and STIs. Department of Disease Control Ministry of Public Health Thailand. Thailand National Guidelines on HIV/AIDS treatment and prevention 2014. Thailand: Thai National HIV Guidelines Working Group; 2014.
  6. Cardillo M, Hagan R, Abadi J, Abadi MA. CD4 T-cell count, viral load, and squamous intraepithelial lesions in women infected with the human immunodeficiency virus. Cancer 2001 Apr;93(2):111-114.
  7. Enebe JT, Dim CC, Nnakenyi EF, Ezegwui HU, Ozumba BC. Effect of low CD4 cell count on cervical squamous intraepithelial lesions among HIV-positive women in Enugu, Southeastern Nigeria. J Clin Diagn Res 2015 Nov;9(11):QC7-QC10.
  8. Chalermchockcharoenkit A, Sirimai K, Chaisilwattana P. High prevalence of cervical squamous cell abnormalities among HIV-infected women with immunological AIDS-defining illnesses. J Obstet Gynaecol Res 2006 Jun;32(3):324-329.
  9. Sirivongrangson P, Bollen LJ, Chaovavanich A, Suksripannich O, Virapat P, Tunthanathip P, Ausavapipit J, Lokpichat S, Siangphoe U, Jirarojwat N, et al. Screening HIV-infected women for cervical cancer in Thailand: findings from a demonstration project. Sex Transm Dis 2007 Feb;34(2):104-107.
  10. Chalermchockcharoenkit A, Chayachinda1 C, Thamkhantho M, Komoltri C. Prevalence and cumulative incidence of abnormal cervical cytology among HIV-infected Thai women: a 5.5-year retrospective cohort study. BMC Infect Dis 2011 Jan;11:8.
  11. Solomon D, Davey D, Kurman R, Moriarty A, O'Connor D, Prey M, Raab S, Sherman M, Wilbur D, Wright T Jr, et al. The 2001 Bethesda system: terminology for reporting results of cervical cytology. JAMA 2002 Apr;287(16):2114-2119.
  12. Getinet M, Gelow B, Sisay A, Mahmoud EA, Assefa A. Prevalence and predictors of Pap smear cervical epithelial cell abnormality among HIV-positive and negative women attending gynecological examination in cervical cancer screening center at Debre Markos referral hospital, East Gojjam, Northwest Ethiopia. BMC Clin Pathol 2015 Sep;15:16.
  13. Wrigth TC Jr, Ellerbrock TV, Chiasson MA, Van Devanter N, Sun XW. Cervical intraepithelial neoplasia in woman infected with human immunodeficiency virus: prevalence, risk factor, and validity of Papanicolaou smears. New York Cervical Disease Study. Obstet Gynecol 1994 Oct;84(4):591-597.
  14. Spinillo A, Capuzzo E, Tenti P, De Santolo A, Piazzi G, Iasci A. Adequacy of screening cervical cytology among human immunodeficiency virus-seropositive women. Gynecol Oncol 1998 May;69(2):109-113.
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