Objective: The study aims at testing the hypothesis that women with high serum beta-human chorionic gonadotropin (β-hCG) and serum lipid profile levels in early second trimester have risk of developing pregnancy-induced hypertension and poor maternal and neonatal outcome. Materials and methods: Serum β-hCG and lipid profile was done in 400 antenatal women between 12 and 24 weeks of gestation and were followed up till delivery. Assessment of serum β-hCG and serum lipids and their predictability for development of pregnancy-induced hypertension and its effect on maternal and fetal outcome were noted. Results: Women with high serum β-hCG levels at 12 to 24 weeks of gestation have 1.67 times more risk of developing pregnancy-induced hypertension (p = 0.035), and poor maternal and perinatal outcome. Raised total cholesterol (TC), triglycerides (TGs), low-density lipoprotein (LDL), very lowdensity lipoprotein (VLDL), TC/high-density lipoprotein (HDL) and LDL/HDL are important risk factors for development of pregnancy-induced hypertension. The mean TC level in women with pregnancy-induced hypertension was 210.1304 ± 50.7392 as compared with 178.0908 ± 47.0994 in normotensive women. The difference in levels of TC (p <0.001), TG (p = 0.0037), LDL (p <0.001), VLDL (p = 0.0193), TC/HDL (p <0.001), and LDL/HDL (p <0.001) in both the groups was statistically highly significant. Conclusion: Maternal dyslipidemia and elevated maternal serum β-hCG at early second trimester are very good noninvasive predictors of pregnancy-induced hypertension. The maternal and perinatal outcome was directly proportional to levels of serum β-hCG and lipid profile.