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VOLUME 10 , ISSUE 1 ( January-March, 2018 ) > List of Articles

ORIGINAL ARTICLE

Evaluation of the Impact of 1,000-unit Intrauterine Injection of Human Chorionic Gonadotropin prior to in vitro Fertilization on Success Rate of Implantation in Infertile Women: A Double-blind Randomized Trial

Masomeh Rezaei, Friba Frhadifar, Ghobad Moradi, Ilnaz Khalatbari

Keywords : Clinical trial, Human chorionic gonadotropin, In vitro fertilization, Intrauterine, Successful implantation

Citation Information : Rezaei M, Frhadifar F, Moradi G, Khalatbari I. Evaluation of the Impact of 1,000-unit Intrauterine Injection of Human Chorionic Gonadotropin prior to in vitro Fertilization on Success Rate of Implantation in Infertile Women: A Double-blind Randomized Trial. J South Asian Feder Obs Gynae 2018; 10 (1):10-14.

DOI: 10.5005/jp-journals-10006-1550

Published Online: 01-02-2018

Copyright Statement:  Copyright © 2018; The Author(s).


Abstract

Aim: Studies have shown that intrauterine injection of human chorionic gonadotropin (hCG) prior to embryo transfer causes success in pregnancy. This study has been done to determine the effect of 1,000-unit intrauterine injection of hCG prior to in vitro fertilization (IVF) on success rate of implantation in infertile women. Materials and methods: This double-blind clinical trial study has been done on two intervention groups (n = 40) and control group (n = 40), who were randomly selected. For the intervention group cases, soft catheter penetrated the uterus and 0.3 cc of liquid fetus culture media with 0.2 cc (1000 unit) of hCG was injected into the uterus. After 7 minutes, the fetus was transferred into the uterus with a soft catheter. In the control group, 0.5 cc of liquid fetus culture media was injected into the uterus and after 7 minutes embryo was transferred into the uterus with another soft catheter. In both groups, the speculum was removed after 3 minutes. Results: The results of this study showed that pregnancy success was the same in both intervention and control groups and it was in eight cases (20%). In this study, 38 cases (95%) of the agonistic cycle type were in the intervention group and 33 (82.5%) cases were in the control group (p > 0.05). On assessment of the situation of pregnancy of each person according to the ultrasound results, the size of right and left ovary in two groups showed no significant differences (p > 0.05). Conclusion: The pregnancy success during the IVF process is related to the quality of the blastocyst in the secretion of many cytokines and hormones in the early days of egg cell implantation, such as interleukin 1 and hCG, and increased level of these hormones and mediators causes disruption of the process of making proteins needed for implantation at the start of the initial development.

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